Evidence

We currently have  110 published reviews and 27 published protocols in Issue 5, 2022 of The Cochrane Library.  We also have a number of registered review titles at varying stages of the editorial process.

List of reviews

Acupuncture for epilepsy 
Antidepressant drugs for narcolepsy
Antidepressants for people with epilepsy and depression
Anticonvulsant therapy for status epilepticus
Antiepileptic drugs for preventing seizures in people with brain tumors
Antiepileptic drugs as prophylaxis for post-craniotomy seizures
Antiepileptic drugs for seizure control in people with neurocysticercosis
Antiepileptic drugs for treating seizures in people with brain tumours                       
Antiepileptic drugs for the primary and secondary prevention of seizures after intracranial venous thrombosis (ICVT)

Antiepileptic drugs for the primary and secondary prevention of seizures after stroke

Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage
Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis 

Antiepileptic drugs for the treatment of severe myoclonic epilepsy in infancy
Antiepileptic drugs for treating seizures in adults with brain tumours
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data - Click here to see figures
Anti-seizure medications for Lennox-Gastaut syndrome

Brivaracetam add-on therapy for drug-resistant epilepsyclick here to see a Patient Decision Aid based on this review

Calcium antagonists as an add-on therapy for drug-resistant epilepsy
Cannabinoids for epilepsy

Carbamazepine versus phenobarbitone monotherapy for epilepsy - Click here to see additional tables/graphs
Carbamazepine versus phenytoin monotherapy for epilepsy - Click here to see additional tables/graphs
Carbamazepine versus valproate monotherapy for epilepsy - Click here to see additional tables/graphs
Care delivery and self-management strategies for adults with epilepsy
Care delivery and self-management strategies for children with epilepsy

Carisbamate add-on therapy for drug-resistant focal epilepsy
Chloral hydrate as a sedating agent for neurodiagnostic procedures in children                                         
Clobazam add-on therapy for drug-resistant epilepsy
Clobazam monotherapy for focal-onset or generalised-onset seizures
Clonazepam add-on therapy for drug-resistant epilepsy
Clonazepam monotherapy for treating people with newly diagnosed epilepsy
Common antiepileptic drugs in pregnancy in women with epilepsy - click here to see additional tables
Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal spikes
Corticosteroids including ACTH for childhood epilepsy other than epilepsy spasms
Drug management for acute tonic-clonic convulsions including status epilepticus in children
Eslicarbazepine acetate add-on for drug-resistant focal epilepsy
EEG for children with complex febrile seizures

Early versus late antiepileptic drug withdrawal for people with epilepsy in remission
Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents
Felbamate as an add-on therapy for drug-resistant epilepsy
Gabapentin add-on for drug-resistant focal epilepsyclick here to see a Patient Decision Aid based on this review
Immediate antiepileptic drug treatment, versus placebo, deferred, or no treatment for first unprovoked seizure

Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy

Immunomodulatory interventions for focal epilepsy syndromes

Interventions for psychotic symptoms concomitant with epilepsy

Intravenous immunoglobulins for epilepsy

Ketogenic diets for drug-resistant epilepsy

Lacosamide add-on therapy for focal epilepsy

Lamotrigine add-on therapy for drug-resistant focal epilepsyclick here to see a Patient Decision Aid based on this review
Lamotrigine add-on therapy for drug-resistant generalised tonic-clonic seizuresclick here to see a Patient Decision Aid based on this review

Lamotrigine versus carbamazepine monotherapy for epilepsy: an individual participant data review

Levetiracetam add-on for drug-resistant focal epilepsy

Losigamone add-on therapy for focal epilepsy

Medications for daytime sleepiness in individuals with idiopathic hypersomnia

Melatonin as add-on treatment for epilepsy

Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child

Non-pharmacological interventions for epilepsy in people with intellectual disabilities

Oxcarbazepine add-on for drug-resistant focal epilepsyclick here to see a Patient Decision Aid based on this review
Oxcarbazepine versus phenytoin monotherapy for epilepsy - an individual participant data review

Oxcarbazepine versus carbamazepine monotherapy for focal onset seizures - an individual participant data review
Pharmacological interventions for epilepsy in people with intellectual disabilities

Pharmacological treatment for Kleine-Levin syndrome
Pharmacological treatment for continuous spike-wave during slow wave sleep syndrome and Landau-Kleffner Syndrome
Pharmacological treatments for preventing epilepsy following traumatic head injury
Phenobarbitone versus phenytoin monotherapy for focal onset seizures and generalized onset tonic-clonic seizures: an individual participant data review

Polyunsaturated fatty acid supplementation for drug-resistant epilepsy
Preconception counselling for women with epilepsy to reduce adverse pregnancy outcome
Pregabalin add-on for drug-resistant focal epilepsy

Pregabalin monotherapy for epilepsy

Prophylactic drug management for febrile seizures in children

Propofol versus thiopental sodium for the treatment of refractory status epilepticus

Psychological treatments for people with epilepsy

Psychological and behavioural treatments for adults with non-epileptic attack disorder

Rufinamide add-on therapy for drug-resistant epilepsy - click here to see a Patient Decision Aid based on this review

Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data reviewClick here to see additional tables/graphs

Subpial transection surgery for epilepsy

Sulthiame add-on therapy for epilepsy

Sulthiame monotherapy for epilepsy

Surgery for epilepsy

The effects of anaesthetic agents on cortical mapping during neurosurgical procedures involving eloquent areas of the brain

Therapeutic monitoring of antiepileptic drugs for epilepsy
The role of high-frequency oscillations in epilepsy surgery planning

Tiagabine add-on for drug-resistant focal epilepsyclick here to see a Patient Decision Aid based on this review
Topiramate add-on for drug-resistant focal epilepsy

Topiramate for juvenile myoclonic epilepsy

Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review

Traditional chinese medicine for epilepsy
Transcranial magnetic stimulation for the treatment of epilepsy
Treatment of epilepsy for people with Alzheimer's disease

Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child

Treatments for seizures in catamenial (menstrual-related) epilepsy

Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP)

Treatment of infantile spasms
Vagus nerve stimulation for focal seizures

Vigabatrin add-on therapy for drug-resistant focal epilepsyclick here to see a Patient Decision Aid based on this review
Vigabatrin versus carbamazepine monotherapy for epilepsy

Vitamins for epilepsy

Yoga for epilepsy

Zonisamide add-on for drug-resistant focal epilepsyclick here to see a Patient Decision Aid based on this review